A 40-year-old man who is morbidly obese and leads a sedentary lifestyle has recently been diagnosed with type 2 diabetes. Which of the following aspects of the man's obesity likely contributed to his new health problem?
A)
The low metabolic needs of adipose tissue mimic a hypoglycemic state and suppress insulin secretion.
B)
Free fatty acids contribute to problems such as beta cell dysfunction and insulin resistance.
C)
Fat tissue initiates glycogenolysis and reliance on glycogen release rather than metabolism of free glucose.
D)
Triglyceride deposits in the pancreas result in damage to beta cells.
Ans:
B
Feedback:
Type 2 diabetes in obese people is thought to link to the actions of free fatty acids, which include beta cell dysfunction (lipotoxicity), insulin resistance, glucose underutilization, and the accumulation of FFAs and triglycerides reduce hepatic insulin sensitivity
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