A female client is receiving methotrexate (Mexate), 12 g/m2 I.V., to treat osteogenic carcinoma. During methotrexate therapy, the nurse expects the client to receive which other drug to protect normal cells?
A. probenecid (Benemid)
B. cytarabine (ara-C, cytosine arabinoside [Cytosar-U])
C. thioguanine (6-thioguanine, 6-TG)
D. leucovorin (citrovorum factor or folinic acid [Wellcovorin])
Answer: D
Explanation: Leucovorin is administered with methotrexate to protect normal cells, which methotrexate could destroy if given alone. Probenecid should be avoided in clients receiving methotrexate because it reduces renal elimination of methotrexate, increasing the risk of methotrexate toxicity. Cytarabine and thioguanine aren't used to treat osteogenic carcinoma.
You might also like to view...
A patient visits the clinic to ask about smoking cessation. He has smoked heavily for 30 years and wants to stop "cold turkey." He asks the nurse, "What symptoms can I expect if I do this?" Which of these symptoms should the nurse share with the patient
as possible symptoms of nicotine withdrawal? Select all that apply. a. Headaches b. Hunger c. Sleepiness d. Restlessness e. Nervousness f. Sweating
The nurse-theorist Roy developed which of the following?
A) Uncertainty in Illness Model B) Health Promotion Model C) Adaptation Model D) Theory of Stress and Coping
Which provides the best data to support the diagnosis of anxiety disorder in clients of any age? Select all that apply
A) Magnetic resonance imaging (MRI) B) Computed tomography (CT scan) C) Presenting symptoms D) Client history E) Prescription list F) Over-the-counter medications
Some competence but low commitment
a. D1 b. D2 c. S2 d. S1