What describes the pathologic changes of sickle cell anemia?

a. Sickle-shaped cells carry excess oxygen.
b. Sickle-shaped cells decrease blood viscosity.
c. Increased red blood cell destruction occurs.
d. Decreased red blood cell destruction occurs.


C
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A Sickled red cells have decreased oxygen-carrying capacity and transform into the
sickle shape in conditions of low oxygen tension.
B When the sickle cells change shape, they increase the viscosity in the area where
they are involved in the microcirculation.
C The clinical features of sickle cell anemia are primarily the result of increased
red blood cell destruction and obstruction caused by the sickle-shaped red blood
cells.
D Increased red blood cell destruction occurs.

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