A client is receiving medroxyprogesterone (Provera) for secondary amenorrhea. Which medications would be contraindicated for this client?
Standard Text: Select all that apply.
1. Barbiturates
2. Rifampin
3. Topiramate
4. Acetaminophen
5. Furosemide
Correct Answer: 1,2,3
Rationale 1: Serum levels of medroxyprogesterone are decreased by barbiturates.
Rationale 2: Serum levels of medroxyprogesterone are decreased by rifampin.
Rationale 3: Serum levels of medroxyprogesterone are decreased by topiramate.
Rationale 4: Acetaminophen does not affect medroxyprogesterone.
Rationale 5: Furosemide does not affect medroxyprogesterone.
Global Rationale: Serum levels of medroxyprogesterone are decreased by aminoglutethimide, barbiturates, primidone, rifampin, rifabutin, and topiramate. Acetaminophen and furosemide do not have this effect.
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