What is the fate of erythrocytes when anaerobic metabolic enzymes are reduced in concentration or absent?
a. Destruction by the liver
b. Destruction by monocytes in the blood
c. Hemolysis
d. Destruction by complement
ANS: C
When metabolic enzymes in the anaerobic pathway of glycolysis are reduced or absent, energy production in the form ATP is diminished. This ultimately results in hemolysis of the RBC because the functions requiring energy in the form of ATP are not fully operational. This hemolysis occurs primarily in the spleen and so is called extravascular hemolysis (as opposed to occurring in the blood vessels, where it would be considered intravascular hemolysis).
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