A client is prescribed verapamil (Calan) and simvastatin (Zocor). To detect a potential adverse effect of this drug combination, the nurse should instruct the client to call her health care provider if which adverse effect is experienced?
1. Tachycardia
2. Muscle pain
3. Dizziness
4. Headache
Correct Answer: 2
Rationale 1: Tachycardia is not associated with statin drugs. Bradycardia can occur as an adverse effect of verapamil (Calan), but this risk is not increased by adding a statin to a drug regimen.
Rationale 2: Muscle pain might indicate myopathy, an adverse effect of simvastatin (Zocor), which is a statin drug. The risk of myopathy is increased when a client takes both a statin drug and verapamil (Calan).
Rationale 3: Dizziness might indicate hypotension, a risk associated with simvastatin that is not increased by verapamil (Calan).
Rationale 4: Headache is not a serious adverse effect of this drug combination.
Global Rationale: Muscle pain might indicate myopathy, an adverse effect of simvastatin (Zocor), which is a statin drug. The risk of myopathy is increased when a client takes both a statin drug and verapamil (Calan). Tachycardia is not associated with statin drugs. Bradycardia can occur as an adverse effect of verapamil (Calan), but this risk is not increased by adding a statin to a drug regimen. Dizziness might indicate hypotension, a risk associated with simvastatin that is not increased by verapamil (Calan). Headache is not a serious adverse effect of this drug combination.
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