If a spontaneous mutation introduced a new allele into a population's gene pool at a chromosomal locus that had previously been static, which of the following would experience the largest change in value as a result?
(A) Average number of gene loci per chromosome
(B) Average frequency of heterozygosity in the gene pool
(C) Nucleotide base-pairing variability at the site of the wobble effect in codon-anticodon recognition
(D) Geographic variability
Ans: (B) Average frequency of heterozygosity in the gene pool
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