A client is prescribed ibuprofen for pain. The nurse is aware that this drug is designed to target which inflammatory mediator to reduce pain?
1. Histamine
2. Leukotrienes
3. Complement
4. Prostaglandins
Correct Answer: 4
Rationale 1: Histamine is not targeted by ibuprofen.
Rationale 2: Leukotrienes are not targeted by ibuprofen.
Rationale 3: Complement is not targeted by ibuprofen.
Rationale 4: Ibuprofen inhibits the production of prostaglandins.
Global Rationale: Some inflammatory mediators are important targets for anti-inflammatory drugs. Ibuprofen is a prostaglandin inhibitor which is effective at treating fever, pain, and inflammation. Ibuprofen does not target histamine, leukotrienes, or complement.
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