The physician is considering prescribing an anti-tumor necrosis factor (TNF) like infliximab for a rheumatoid arthritis patient
Which of the following statements is accurate about the advantages of using a TNF inhibitor?
A)
"Since TNF inhibitors have few side effects, these drugs will fit well into your regimen."
B)
"Your disease-modifying antirheumatic drug (DMARD) methotrexate has more cardiovascular side effects than TNF inhibitors."
C)
"TNF inhibitors help slow the disease progression and improve your ability to perform routine ADL functions."
D)
"Not only do TNF inhibitors control your disease better but they also will interrupt the inflammatory cascade at several levels."
Ans:
C
Feedback:
Second-line antirheumatic drugs include anti-TNF drugs such as etanercept, infliximab, and adalimumab. These drugs are biologic response-modifying agents or TNF inhibitors that block TNF-a, one of the key proinflammatory cytokines in RA. Anti-TNF-a agents have shown significant efficacy although they do have some potential adverse side effects. Evidence indicates that CV side effects are not different for TNF inhibitors than for DMARDs. The TNF inhibitor agents also have been shown to inhibit radiologic disease progression and improve functional outcomes.
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