A client is receiving antibiotic treatment for a wound abscess. What does the nurse recognize that drug distribution to this area requires, in order to be effective?
1. The drug to be lipid soluble
2. Adequate blood perfusion to the area
3. The drug to be bio-available in an acidic environment
4. Use of a topical antibiotic
Correct Answer: 2
Rationale 1: Lipid-soluble medications have a high affinity for adipose tissue and may not stay in the vascular compartment long enough to reach the abscess.
Rationale 2: Antibiotics can have difficulty reaching areas of necrotic or abscessed tissues, unless they have an adequate blood supply available.
Rationale 3: Ionization of a drug in an acidic environment affects absorption, not distribution, of the drug.
Rationale 4: A topical antibiotic might be indicated for external wounds, but abscesses are often internal and require medication to be delivered via blood vessels, unless they have been incised and drained.
Global Rationale: Antibiotics can have difficulty reaching areas of necrotic or abscessed tissues, unless they have an adequate blood supply available. Lipid-soluble medications have a high affinity for adipose tissue and may not stay in the vascular compartment long enough to reach the abscess. Ionization of a drug in an acidic environment affects absorption, not distribution, of the drug. A topical antibiotic might be indicated for external wounds, but abscesses are often internal and require medication to be delivered via blood vessels, unless they have been incised and drained.
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