The nurse is reviewing laboratory results for a client taking dantrolene sodium (Dantrium). The nurse should notify the physician if which of the following is noted on the laboratory report sheet?
1. Creatinine level, 0.6 mg/dL
2. Platelet count, 290,000/mm3
3. Blood urea nitrogen (BUN) level, 9 mg/dL
4. Lactic dehydrogenase (LDH) level, 600 units/L
4
Rationale: Dose-related liver damage is the most serious adverse effect of dantrolene. To reduce the risk of liver damage, liver function tests should be performed prior to treatment and throughout the treatment interval. It is administered in the lowest effective dosage for the shortest time necessary. The LDH level reported in "lactic dehydrogenase (LDH) level, 600 units/L" is high (normal level is 140 to 280 units/L). The other options indicate normal laboratory results.
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