A client is receiving orlistat (Alli) to aide in weight reduction. The nurse reviews the all other drugs taken by the client. Which drug should not be taken concurrently with orlistat?
1. Furosemide (a diuretic)
2. Cyclosporine (an antibiotic)
3. Warfarin (an anticoagulant)
4. Ibuprofen (a nonsteroidal anti-inflammatory)
Correct Answer: 2
Rationale 1: Orlistat (Alli) can be taken with diuretics if necessary. No adverse reactions have been reported.
Rationale 2: Orlistat decreases the absorption of cyclosporine; the two drugs should not be used concurrently.
Rationale 3: Vitamin K levels may decrease in clients taking orlistat, which can affect anticoagulation produced by warfarin. The medication, however, is not contraindicated when taking orlistat.
Rationale 4: Orlistat (Alli) does not interact with ibuprofen.
Global Rationale: Orlistat decreases the absorption of cyclosporine; the two drugs should not be used concurrently. Vitamin K levels may decrease in clients taking orlistat, which can affect anticoagulation produced by warfarin. The medication, however, is not contraindicated when taking orlistat. The drug does not interact with ibuprofen or diuretics.
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