A client is prescribed probenecid and several other medications. When reviewing the client's medication record, the nurse determines that the client is at risk for possible toxicity if which of the following is also prescribed? Select all that apply
A) Phenobarbital (Luminal)
B) Valproic acid (Depakote)
C) Diazepam (Valium)
D) Diclofenac (Voltaren)
E) Acyclovir (Zovirax)
Ans: A, C, D, E
Feedback:
Probenecid (Benemid) increases the serum levels of the following medications, placing the client at risk for toxicity: penicillins, cephalosporins, acyclovir, rifampin, sulfonamides, barbiturates (phenobarbital), benzodiazepines (diazepam), and NSAIDs (diclofenac).
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