The nurse reads that a drug undergoes enterohepatic recirculation. How would the nurse explain this process to a colleague?
1. This drug must be given several times a day.
2. The drug will have a very low therapeutic effect.
3. The drug will be concentrated in the liver.
4. The drug might have a prolonged activity in the body.
Correct Answer: 4
Rationale 1: The drug will not need to be given several times a day.
Rationale 2: Enterohepatic recycling will not necessarily lower the therapeutic effect.
Rationale 3: The drugs are recirculated through the liver but are not concentrated in the liver.
Rationale 4: Drugs secreted into the bile are sent back to the liver through enterohepatic recirculation and can be recirculated several times, thus prolonging their activity.
Global Rationale: Drugs secreted into the bile are sent back to the liver through enterohepatic recirculation and can be recirculated several times, thus prolonging their activity. The drug will not need to be given several times a day. Enterohepatic recycling will not necessarily lower the therapeutic effect. The drugs are recirculated through the liver but are not concentrated in the liver.
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