Fine structure genetic maps of the human genome are now constructed using either restriction fragment length polymorphisms (RFLPs) which are found about 1/6000 bp
or single nucleotide polymorphisms (SNPs) which are found about 1/1330 bp. Would you expect RFLPs or SNPs to be located only in the coding regions of genes or in noncoding and repetitive sequences as well?
What will be an ideal response?
Ans: The power of using both RFLPs and SNPs for genetic maps is they are found independently of gene function and can be located anywhere in the genome. Therefore, they are found far more frequently than the number of identified genetic variants that change phenotype, allowing for far more detailed maps to be constructed. The older maps made using recombination frequencies between loci often had huge gaps where there were no variants or no variants that resulted in observable phenotypic changes.
You might also like to view...
The _______ refers to the genetic composition of an individual
A. character B. genotype C. phenotype D. dominant trait E. recessive trait
An effective means used early in the 19th century to clear water of the majority of bacteria was the use of
A. chlorine. B. iodine. C. alcohol. D. sand filters
No animal cell has a _____
a. plasma membrane c. lysosome b. flagellum d. cell wall
Which of the following is (are) NOT characteristic(s) of the pathways activated by second messengers?
a) Each signaling pathway consists of a series of distinct proteins that operate in sequence. b) Some phosphatases and protein kinases in the pathway have numerous proteins as their substrates; others act on only a single protein substrate or a single amino acid of a protein substrate. c) Alterations in the conformations of signaling proteins are often accomplished by protein kinases and protein phosphatases that, respectively, add or remove phosphate groups from other proteins. d) Each protein in the pathway typically acts by altering the conformation of the previous (upstream) protein in the series, an event that activates or inhibits the protein.