The nurse is caring for a premature infant who is receiving an infusion of a substance in an attempt to close a patent ductus arteriosus. The nurse will explain to the mother that this substance is:
a. indomethacin, which inhibits the synthesis of prostaglandin, the substance that maintains the patency of the ductus arteriosus
b. a hypertonic saline solution that will draw the ductus into closure
c. a cardiac stimulant, which increases the firing in the Purkinje fibers, thus causing a greater force for closing the ductus arteriosus
d. an estrogen product, which will build up the tissue in the ductus arteriosus and cause an eventual closure
A
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A Correct. The nurse will explain to the mother that indomethacin inhibits the synthesis of prostaglandin, the substance that maintains the patency of the ductus arteriosus. The ductus arteriosus is a direct connection between the main pulmonary artery and the aorta. It is necessary in the fetus for survival. In the premature infant the PDA does not close based on developmental immaturity; however, it does close in the full term infant.
B Incorrect. Indomethacin is not a hypertonic saline solution that will draw the ductus into closure.
C Incorrect. Indomethacin is not a cardiac stimulant, which increases the firing in the Purkinje fibers, thus causing a greater force for closing the ductus arteriosus.
D Incorrect. Indomethacin is not an estrogen product, which will build up the tissue in the ductus arteriosus and cause an eventual closure.
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