A 60-year-old man died two days after a thrombotic occlusion of the right coronary artery. Histologically, the myocardial cells appeared necrotic and had small condensed dark blue nuclei. This nuclear change is called
A. karyolysis
B. karyorrhexis
C. pyknosis
D. heterochromatin
E. euchromatin
C
Condensation of nuclei in necrotic cells is called pyknosis (from the Greek word pyknos, meaning dense). Karyolysis and karyorrhexis are two other nuclear changes found in necrotic cells. Karyolysis is characterized by dissolution of the nucleus, whereas karyorrhexis is associated with fragmentation of the nucleus into smaller pieces. Heterochromatin and euchromatin are parts of the normal nucleus: heterochromatin represents the condensed transcriptionally active chromatin and euchromatin represents the finely dispersed inactive chromatin.
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