Ketoconazole is used as an alternative to amphotericin B for less severe systemic mycosis. Which are the primary reasons for choosing ketoconazole? (Select all that apply.)
a. It can be given orally.
b. It can be used safely in patients with he-patic dysfunction.
c. It can be given once weekly rather than daily.
d. It is effective for severe, acute infections.
e. It is less toxic.
A, E
Ketoconazole is given instead of amphotericin B because it is less toxic and can be administered orally. Amphotericin B is administered intravenously. Ketoconazole is hepatotoxic; it is given daily. Ketoconazole is less useful for severe, acute infections.
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