The patient tells the nurse that he is on many medications and questions how they all get to the right places. What are the best responses by the nurse? Note: Credit will be given only if all correct choices and no incorrect choices are selected. Standard Text: Select all that apply

Question

1. "It depends on how much protein you have in your body."
2. "It depends on the health of your kidneys."
3. "It depends on whether they are fat based or water based."
4. "It depends on the amount of blood flow to your body tissues."
5. "It depends on the health of your liver."

Answer 1

1,3,4
Rationale 1: Distribution of drugs depends on protein binding.
Rationale 2: The health of the kidneys refers to excretion, not distribution.
Rationale 3: Distribution of drugs depends on the lipid solubility of the drug.
Rationale 4: Distribution of drugs depends on the amount of blood flow to body tissues.
Rationale 5: The health of the liver refers to metabolism, not distribution.
Global Rationale: Distribution of drugs depends on the amount of blood flow to body tissues, the lipid solubility of the drug, and protein binding. The health of the liver refers to metabolism, not distribution. The health of the kidneys refers to excretion, not distribution.