A nurse is reviewing medication records of older adults living in extended care. Which concepts about the pharmacotherapy of older adults should be considered?Note: Credit will be given only if all correct choices and no incorrect choices are selected. Select all that apply.
A. Plasma-binding of drugs is greater in those over age 65.
B. Drug distribution is slowed in the older adult.
C. The half-life of many drugs is lessened in older adults.
D. First-pass metabolism is reduced in the older adult.
E. Changes in the kidney may result in decreased drug excretion.
Answer: E
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