Loop diuretics
1. inhibit reabsorption of sodium and chloride in the loop of Henle.
2. block sodium in the distal and proximal loops.
3. block aldosterone.
4. promote excretion of water by adding sodium to the filtrate.
1
Rationale 1: Loop diuretics inhibit sodium in the loop of Henle and increase urine output.
Rationale 2: Thiazide diuretics block sodium in the distal tubule and nephron.
Rationale 3: Potassium-sparing diuretics block aldosterone.
Rationale 4: Some miscellaneous diuretics have this mechanism.
Global Rationale: Loop diuretics inhibit sodium in the loop of Henle and increase urine output. Thiazide diuretics block sodium in the distal tubule and nephron. Potassium-sparing diuretics block aldosterone. Some miscellaneous diuretics add sodium to the filtrate.
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