How does leptin affect appetite and is it involved in the development of obesity?
What will be an ideal response?
Answers will vary.
Leptin is a protein made by adipose tissue; it functions as a hormone to reduce food intake, thus decreasing body fat. The obesity gene (ob gene) codes for the synthesis of leptin. When the ob gene is functioning normally, leptin is made and signals satiety. However, when there is a mutation in the ob gene and leptin is not made in sufficient quantities, the desire to eat is increased dramatically, metabolic rate declines (which reduces energy output), and weight gain occurs. Because treating people with leptin doesn't cause significant weight loss, experts suggest that, instead of protecting against obesity, leptin may be more important for signaling low body fat stores and setting in motion adaptations that promote energy conservation, delaying the effects of starvation.
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