Which of the following risk factors are associated with an increase in the incidence of pulmonary embolism? 1. Advanced age 2. Immobilization 3. Multiple injuries from trauma 4. Positive smoking history

a. 2 and 3 only
b. 1, 2, and 3 only
c. 4 only
d. 2, 3, and 4 only


ANS: B
Several conditions enhance the intravascular coagulability of the blood and predispose to venous thromboembolic disease (Box 28-1). The most frequent causes of an inherited hypercoagulable state are the factor V Leiden mutation and the prothrombin gene mutation, which together ac-count for 50% to 60% of cases. The major acquired risk factors for VTE include recent major surgery, trauma, immobilization, antiphospholipid antibody syndrome, malignancy, pregnancy, oral contraceptives, and myeloproliferative disorders.

Health Professions

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