A patient who is not on heparin and has no history of a factor deficiency has a prolonged partial thromboplastin time (PTT). Select the test that should be performed next
a. High-sensitivity C-reactive protein
b. Mixing studies for lupus anticoagulant
c. Thrombin time (TT)
d. Lipid panel
ANS: B
The lupus anticoagulant results in a prolonged PTT. It is characterized by lack of correction when the patient plasma is mixed 1:1 with normal platelet poor plasma and the PTT repeated. None of the other listed findings prolong the PTT.
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