Mr. Page has been treated previously with corticosteroids and mesalamine. His physician had planned to start Humira prior to this admission. Explain the mechanism for each of these medications in the treatment of Crohn's

Identify any drug-nutrient interactions for each.


• Corticosteroids: Anti-inflammatory; reduction of lymphocytes; increased neutrophils; decreased production of prostaglandins.
• Drug-nutrient interactions: hyperglycemia, nitrogen wasting, and increased risk of osteoporosis (increased excretion of calcium). May result in hypokalemia, as well.
• Mesalamine: Also known as 5-aminosalicylic acid/5-ASA. Anti-inflammatory—inhibits cyclooxygenase, which reduces synthesis of prostaglandins.
• Drug-nutrient interactions: none
• Humira: Anti-TNF antibody that inhibits TNF-α, which reduces the inflammatory response.
• Drug-nutrient interactions: none

Nutritional Science

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