Avery, MacLeod, and McCarty (1944) demonstrated that DNA was the molecule of heredity by treating heat-killed Streptococcus pneumoniae S (smooth) strain with DNase, thereby preventing transfer of the "transforming substance" from the killed S strain to the live R (rough) strain when the two were mixed together and injected into mice. Another way that one could demonstrate transformation in

bacteria would be to extract DNA from

A) an R strain and mix with cells of an S strain.
B) both S and R strains and mix to allow recombination to take place.
C) an ampicillin-sensitive strain and mix with cells of an ampicillin-resistant strain.
D) an S strain and mix with cells of an R strain.
E) none of the above


D) an S strain and mix with cells of an R strain.

Biology & Microbiology

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