Which neurotransmitter is MOST affected by antipsychotic agents?
a. dopamine
b. epinephrine
c. histamine
d. serotonin
A
Dopamine is the neurotransmitter most affected by antipsychotic agents. Specifically, all antipsychotics block dopamine receptor D2 . Illnesses such as schizophrenia (and perhaps other psychoses) involve excessive activation of dopamine receptor D2, and antipsychotics seek to alleviate the illness by blocking such activation. Clozapine also has an effect on dopamine receptors D1 and D4 .
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