A faculty member is discussing systemic lupus erythematosus (SLE) with a group of nursing students. Which pathophysiological process does the nurse describe as the major problem in this disorder?
A.
Autoimmune process creates antigen-antibody complexes that damage tissues
B.
Genetic defect linked strictly to male offspring leading to organ damage
C.
Limited autoimmune process destroys tissues in specific target organs
D.
Rapidly progressive disease triggered by hormonal changes such as pregnancy.
ANS: A
SLE is an autoimmune disorder in which antigen-antibody complexes are formed and deposited widely throughout the body, damaging many organs and tissues. It is tied to a genetic disposition but is not solely genetic in origin; it affects females more than males. The destruction is widespread, not limited to a few target organs. The disease is characterized by exacerbations and remissions.
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