Which of the following would the nurse identify as a factor that alters drug response in children and infants? Select all that apply
A) Slower gastric emptying
B) Greater surface area
C) Less protein binding
D) Decreased body water content
E) Less cutaneous fat
Ans: A, B, C, E
Feedback:
Children and infants are not small adults; therefore, they have altered pharmacokinetics. Factors that alter pharmacokinetics in children include slower gastric emptying, less cutaneous fat, greater surface area, increased body water content, less protein binding, and immature hepatic and renal function.
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