Explain wear-and-tear theories of aging.

What will be an ideal response?


(answers may vary) Wear-and-tear theories are built on the premise that things wear out with use. Errors in the replication of cells and accumulation of damaging byproducts eventually destroy the organism. Cytotoxicity results when damaged cell components reach critical mass and become toxic to healthy cells. Glucose binding to proteins leads to accumulation of AGEs; cross-linking between cells stiffens collagen fibers, including those in tendons, ligaments, blood vessels, and kidneys. According to wear-and-tear theories, the accumulation of damaged cells and waste byproducts leads to declining function and aging.

Nutritional Science

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What will be an ideal response?

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