Huntington disease is caused by expansion of the trinucleotide repeat region of the HD gene that results in the production of a Huntingtin protein with an expanded number of glutamines. An animal model with most features of this syndrome could be created by
A) adding a transgene containing a disease-causing mutant allele of the HD gene to a mouse or primate genome.
B) adding a transgene containing a wild-type copy of the HD gene to a mouse or primate genome.
C) knocking out both copies of the HD gene from a mouse or primate genome.
D) knocking out one copy of the HD gene from a mouse or primate genome.
A) adding a transgene containing a disease-causing mutant allele of the HD gene to a mouse or primate genome.
You might also like to view...
Our ability to respond to moderate heat and cold is due to
A. mechanoreceptors. B. thermoreceptors. C. nociceptors. D. electromagnetic receptors. E. chemoreceptors.
Genetic studies of an animal show that eye color is controlled by an autosomal gene with the dominant allele (R) for red
eye color and the recessive allele (r) for yellow eye color. A second autosomal gene has the dominant allele (T) for paws with thumbs and the recessive allele (t) for paws without thumbs. The genetic cross RRTT x rrtt creates offspring with genotype RrTt. One of those dihybrids is mated in a testcross (RrTt x rrtt). Based on the principle of independent assortment, the testcross should produce offspring with the phenotype ratio ____.
a. 3 red-eyed with thumbs : 1 yellow-eyed without thumbs b. 1 red-eyed with thumbs : 1 yellow-eyed with thumbs: 1 red-eyed without thumbs: 1 yellow-eyed without thumbs c. 1 red-eyed with thumbs : 1 yellow-eyed without thumbs d. 9 red-eyed with thumbs : 3 yellow-eyed with thumbs: 3 red-eyed without thumbs: 1 yellow-eyed without thumbs e. 3 yellow-eyed with thumbs : 1 red-eyed without thumbs
Hypoxia
a. causes hypoventilation. b. depletes the tissues of carbon dioxide. c. inhibits the brain's respiratory centers. d. may be the result of changes in altitude. e. results in lowered body temperature
The sigma subunit of bacterial RNA polymerase ___________________
(a) contains the catalytic activity of the polymerase. (b) remains part of the polymerase throughout transcription. (c) recognizes promoter sites in the DNA. (d) recognizes transcription termination sites in the DNA.