The client receives zidovudine (Retrovir) for treatment of human immunodeficiency virus (HIV) infection. The nurse would increase assessment surveillance for which adverse reactions from this treatment?
1. The client complains of fatigue and generalized weakness.
2. The client complains of new onset headache.
3. Constipation
4. Edema
5. The client's liver is palpable on physical examination.
Correct Answer: 1,2,5
Rationale 1: Fatigue and weakness are experienced by many clients taking zidovudine.
Rationale 2: Headache will occur in the majority of clients taking this medication.
Rationale 3: Diarrhea is a more expected adverse reaction.
Rationale 4: Edema is not an expected adverse reaction.
Rationale 5: Hepatomegaly can occur and may require dosage adjustments or discontinuation of this drug.
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