What clinical manifestation should the nurse periodically monitor for while a client is being administered valproic acid?
A) Hepatotoxicity
B) Hypertensive crisis
C) Orthostatic hypotension
D) Hyperalertness
A
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The nurse should closely monitor a client on valproic acid, Depakote or Depakene, for hepatotoxicity. Frequent liver function tests and serum ammonia concentrations may be ordered. When a monoamine oxidase inhibitor is mixed with foods containing tyramine, another monoamine, clients are likely to develop a potentially fatal hypertensive crisis, and not when taking valproic acid. Risk for orthostatic hypotension from psychotropic drugs is increased in older adults because of decreased functioning of the blood pressure-regulating mechanism. Some clients administered valproic acid experience sedation and ataxia.
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