During a secondary immune response, high-affinity IgG antibodies are produced. Which of the following best explains why low-affinity IgM antibodies are not made?
a. Naive pathogen-specific B cells are suppressed by negative signaling through Fc?RIIB1.
b. Naive pathogen-specific B cells isotype switch and hypermutate much more quickly during secondary immune responses.
c. Memory B cells outnumber naive B cells.
d. Low-affinity IgM antibodies are made only when antigen concentration is exceedingly high.
A
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