A patient, admitted with an infected wound, is demonstrating signs of improvement. The nurse realizes that this improvement is most likely because of
1. cortisol released from the adrenal glands.
2. hypothalamus activating white blood cells.
3. endothelial cells releasing mediators to contain the infection.
4. activation of fibrinolysis.
3
Rationale: Mediators, bioactive substances that stimulate physiologic changes in cells, are released from endothelial cells. It is these mediators that control inflammation, activate coagulation, deposit fibrin, and inhibit fibrinolysis to contain the inflammatory activity to the site of the infection. The wound infection was not contained because of the release of cortisol by the adrenal glands. The hypothalamus does not activate white blood cells. Fibrinolysis needs to be inhibited and not activated to contain the infection to the leg wound.
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