A client with posttraumatic stress disorder (PTSD) who is having recurring nightmares may be prescribed which of the following medications (as an off-label use) to treat the nightmares and improve sleep?
A) Lorazepam, a benzodiazepine
B) Prazosin, an alpha1 inhibitor
C) Metoprolol, a b-adrenergic blocking agent
D) Zolpidem, a sedative
Ans: B
Off-label use of prazosin, an alpha1 inhibitor, has recently been shown to be effective in treating nightmares and improving sleep in clients with PTSD. Selective serotonin reuptake inhibitors (SSRIs), benzodiazepines, and b-blockers also have been shown to be effective in reducing the symptoms of PTSD.
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