What pathologic process is believed to be responsible for the development of postinfectious glomerulonephritis?
a. Infarction of renal vessels
b. Immune complex formation and glomerular deposition
c. Bacterial endotoxin deposition on and destruction of glomeruli
d. Embolization of glomeruli by bacteria and fibrin from endocardial vegetation
ANS: B
After a streptococcal infection, antibodies are formed, and immune-complex reaction occurs. The immune complexes are trapped in the glomerular capillary loop. Infarction of renal vessels occurs in renal involvement in sickle cell disease. Bacterial endotoxin deposition on and destruction of glomeruli is not a mechanism for postinfectious glomerulonephritis. Embolization of glomeruli by bacteria and fibrin from endocardial vegetation is the pathology of renal involvement with bacterial endocarditis.
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