An increase in the level of RANKL would result in:
A) Fusing of the epiphysis and metaphysis in long bones
B) Changes in the rate of bone remodeling
C) Decreased production of PTH
D) Increased vitamin D activation
Ans: B
Feedback:
Correct regulation of the RANKL/RANK/OPG pathway is necessary for normal bone remodeling and a balance between bone resorption and bone formation. The pathway in general, and levels of RANKL in particular, does not directly influence levels of PTH and vitamin D. RANKL has no bearing on the fusing of epiphyses and metaphyses.
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