What is the pathologic process causing the decreased GFR associated with acute glomerular nephritis?
A. Decreased renal-induced constriction of the renal arteries
B. Necrosis of 70% or more of the nephrons secondary to increased kidney intersti-tial hydrostatic pressure
C. Scar tissue formation throughout the proximal convoluted tubule secondary to toxin-induced collagen synthesis
D. Thickened capillary membranes secondary to immune complex deposition and cellular proliferation
D
Most forms of glomerulonephritis are associated with accumulation of immune complexes in the glomeruli and glomerular capillaries, thickening the capillaries and impeding filtration. The im-mune complexes activate many mediators, including complement, leukocytes, and coagulation proteins, responsible for the resultant renal tissue injury.
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