A client will be taking interferon alfa-2b (Intron A) as treatment for hairy cell leukemia. The nurse advises this client about which common adverse effects?
Standard Text: Select all that apply.
1. Nausea
2. Fever
3. Dizziness
4. Headache
5. Rash
Correct Answer: 1,2,3,4
Rationale 1: Nausea is a common adverse effect of interferon alfa-2b.
Rationale 2: Fever is a common adverse effect of interferon alfa-2b.
Rationale 3: Dizziness is a common adverse effect of interferon alfa-2b.
Rationale 4: Headache is a common adverse effect of interferon alfa-2b.
Rationale 5: Rash is not a common adverse effect of interferon alfa-2b and should be reported.
Global Rationale: The most common adverse effect of IFN therapy is a flulike syndrome of fever, chills, dizziness, weight loss, and fatigue that occurs in about 50% of patients and that usually diminishes as therapy progresses. Fatigue may be severe at higher doses. Headache, nausea, vomiting, diarrhea, and anorexia are relatively common. Rash is not a common effect and should be reported.
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