A patient has an increased reaction to a drug following a change in her dietary habits. Which change would most likely be the cause?
1. Increased intake of grapefruit juice
2. Reduced intake of alcohol
3. Increased fiber intake
4. Reduced intake of citrus fruit
1
Rationale 1: Grapefruit juice lowers the activity of enzymes in the GI system that break down medications. This in turn results in higher medication absorption into the bloodstream.
Rationale 2: A reduced intake of alcohol would not likely produce an increased reaction to a drug.
Rationale 3: A reduced intake of fiber would not likely produce an increased reaction to a drug.
Rationale 4: A reduction in citrus fruit intake would likely cause a lowered drug reaction.
Global Rationale: Grapefruit juice lowers the activity of enzymes in the GI system that break down medications. This in turn results in higher medication absorption into the bloodstream. A reduction in citrus fruit intake would likely cause a lowered drug reaction. A reduced intake of alcohol or fiber would not likely produce an increased reaction to a drug.
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