To best prevent a systemic effect from a topically applied medication patch, the nurse must:
1. Alternate application sites regularly
2. Avoid applying the medication to broken skin
3. Monitor the client for signs of an irritating rash
4. Remove residual medication with mild soap and water
ANS: 2
Systemic effects often occur if a client's skin is thin or broken, if the medication concentration is high, or if contact with the skin is prolonged. The remaining options are more directed towards preventing skin irritations.
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