A patient is admitted to the intensive care unit for treatment of shock. The prescriber orders isoproterenol (Isuprel). The nurse expects this drug to increase tissue perfusion in this patient by activating:
a. alpha1 receptors to cause vasoconstriction.
b. alpha1 receptors to increase blood pressure.
c. beta1 receptors to cause a positive inotropic effect.
d. beta2 receptors to cause bronchodilation.
ANS: C
Isoproterenol is used for shock because of its actions on beta1 receptors in the heart. It has a positive inotropic effect, which improves cardiac output and thus increases tissue perfusion. Isoproterenol does not affect alpha1 receptors. Although it activates beta2 receptors to cause bronchodilation, this is not indicated for the treatment of shock.
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