What are the effects of histamine binding to the H1 receptor on smooth muscle, mucosal epithelia, and the endothelial cells of blood vessels
What will be an ideal response?
When smooth muscle cells bind histamine using H1 receptors, they contract. In combination with increased mucus production by mucosal epithelium this produces a variety of effects, for example, wheezing due to bronchial constriction, coughing, sneezing, watery eyes, nasal discharge, itchiness, and, if the reaction occurs in the gut, vomiting and diarrhea. When endothelial cells of blood vessels bind histamine, an increase in vascular permeability enables the entry of fluid (edema) and leukocytes into affected tissues.
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