What is the reason for a paraplegic patient to receive baclofen (Lioresal)?
a. It interrupts reflexes at the level of the spinal cord.
b. It acts directly on the skeletal muscles to reduce spasticity.
c. It interrupts transmission of impulses from motor nerves to muscles at the skeletal neuromuscular junction.
d. It produces generalized mild weakness of skeletal muscles and decreases the force of reflex muscle contractions.
ANS: A
Baclofen is a gamma aminobutyric acid derivative that interrupts polysynaptic reflexes at the level of the spinal cord. Baclofen does not appear to act directly on the skeletal muscles. Interrupting transmission of impulses from motor nerves to muscles at the skeletal neuromuscular junction is the mechanism of action of neuromuscular-blocking agents. Producing generalized mild weakness of skeletal muscles and decreasing the force of reflex muscle contractions is the mechanism of action of dantrolene.
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