Interactions that affect drug or nutrient metabolism and occur after the digestive and absorptive processes are complete are classified as:
1. Alteration in excretion.
2. Alteration in bioavailability.
3. Alteration in metabolism.
4. Alteration in inhibition.
3
Rationale: Interactions that affect drug or nutrient metabolism occurring after digestion and absorption are complete and the substances are in the circulation en route to tissues are referred to as alterations in metabolism. Alterations in excretion refer to the elimination of metabolic byproducts. Alterations in bioavailability are the result of a change in absorption of drugs or nutrients. Inhibition results from alteration in the use of enzymes during metabolism and results in increased drug absorption.
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