In the process of interventional research on the efficacy of omega 3 fish oil in decreasing blood sugar in diabetic adults, which event would appear just before widespread dissemination?
a. A randomized clinical trial testing the effects of omega 3 fish oil on blood sugar in 300 ambulatory diabetic adults
b. Proof of the safety of the prescribed dose of omega 3 fish oil
c. Several replication studies of the effects of omega 3 fish oil on blood sugar in hundreds of ambulatory diabetic adults
d. Efficacy studies to establish outcome effects of omega 3 fish oil and optimal treatment regimens in adults
ANS: C
Theory-based intervention research can begin with a concept analysis of the problem or the intervention intended to address it. By dissecting the components of problems and plausible solutions, investigators can gain clarity of the issues at hand. After pre-clinical work, proof of the safety of an intervention and estimates of effect occur; following that are efficacy studies to establish outcome effects and optimal treatment conditions. Then a randomized controlled trial is conducted. This is followed by replication and/or long-term follow-up.
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