Singer Michael Jackson allegedly abused alprazolam (Xanax) and propofol (Diprivan), an anesthetic. Which inference applies?
a. The singer had a substance dependence problem, but these medications had no interaction.
b. Potentially lethal sedation and CNS depression would be expected with this drug combination.
c. Tolerance to propofol probably developed very quickly in the presence of alprazolam.
d. This drug combination was safe, but the singer needed closer medical supervision.
B
Propofol, an anesthetic, would have a predictable additive effect with alprazolam in producing significant sedation and CNS depression. The singer probably needed closer medical supervision, but one cannot state that the combination of drugs was safe. Tolerance to alprazolam would occur regardless of use of propofol.
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