The nurse is reviewing the steps of the negative feedback regulation of thyroid hormone. The nurse would place these steps in which sequence?
1. Blood levels of thyroid hormone rise.
2. Hypothalamus secretes thyroid-releasing hormone (TRH).
3. Secretion of TSH and TRH are suppressed.
4. T3 and T4 are secreted.
5. The anterior pituitary secretes thyroid-stimulating hormone (TSH).
2,5,4,1,3
Global Rationale: When blood level of thyroid hormone is low, the hypothalamus secretes thyroid-releasing hormone, which stimulates secretion of thyroid-stimulating hormone. This stimulates production and secretion of T3 and T4. As the levels of thyroid hormones rise, the secretion of TSH and TRH are suppressed.
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