Explain the potential role of diet in the development of NAFLD. Specifically address the roles of simple sugars, fructose, refined carbohydrates, and saturated fat
What will be an ideal response?
• In one systematic review, fructose appears to not be related to NAFLD when substituted isocalorically into the diet. But, when providing it in excess of energy needs and very high doses, some contribution to increasing ALT levels can be observed.
• Simple sugars, refined carbohydrates, and saturated fat may exacerbate the fat accumulation observed within NAFLD (thought to be related to the elevated insulin levels with elevated serum levels of these substances).
• Low-carbohydrate, low-fat, and high-protein diets appear to be beneficial for NAFLD patients
• Substitution of carbohydrate for MUFA incorporation into the diet may have even greater effects on NAFLD, suggesting that the Mediterranean diet has nutritional therapeutic potential.
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A) ?case control study B) ?human intervention study C) ?cohort study D) ?cross-sectional study
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